Gentamicin Ototoxicity Requires Functional Mechanotransducer Channels
نویسندگان
چکیده
منابع مشابه
Functional Hair Cell Mechanotransducer Channels Are Required for Aminoglycoside Ototoxicity
Aminoglycosides (AG) are commonly prescribed antibiotics with potent bactericidal activities. One main side effect is permanent sensorineural hearing loss, induced by selective inner ear sensory hair cell death. Much work has focused on AG's initiating cell death processes, however, fewer studies exist defining mechanisms of AG uptake by hair cells. The current study investigated two proposed m...
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Rapid sensory transduction in hair cells is made possible by the direct coupling of stereocilia displacement to ion channels. This week, Ricci et al. examined the extraordinarily fast (and thus difficult to measure) kinetics of these mechanotransducer (MET) channels, and how kinetics shapes transduction. MET channels open rapidly in response to deflections of the hair bundle and then adapt (clo...
متن کاملAn energy-dependent step in aminoglycoside ototoxicity: prevention of gentamicin ototoxicity during reduced endolymphatic potential.
Guinea pigs received a bolus of gentamicin (10 mM for 5 min) by perilymphatic perfusion which normally led to an irreversible loss of the cochlear microphonic potential (CM). Various experimental conditions that reduced the endolymphatic potential (EP) were then superimposed on the gentamicin application. Reversible reductions in EP (and, concomitantly, in CM) were induced by asphyxia (3 min), ...
متن کاملThe effect of radiotherapy on gentamicin ototoxicity: an animal model.
OBJECTIVE Patients undergoing radiotherapy (RT) often present with serious bacterial infections requiring the use of antibiotic treatment. Gentamicin is a commonly used aminoglycoside antibiotic, whose ototoxicity remains a major problem in clinical use. The objective of this study was to determine whether radiation exposure can influence gentamicin-induced ototoxicity. STUDY DESIGN Prospecti...
متن کاملN-acetylcysteine Prevents Gentamicin Ototoxicity in a Rat Model.
OBJECTIVE The possible preventive effect of N-acetylcysteine (NAC) in gentamicin ototoxicity was studied with auditory brain stem responses (ABRs), otoacoustic emissions (OAEs), and histopathological investigation of the cochlea. MATERIALS AND METHODS This study is conducted on 36 rats in three groups. Gentamicin, gentamicin plus NAC, and NAC alone were intraperitoneally administered for 15 d...
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ژورنال
عنوان ژورنال: Otolaryngology–Head and Neck Surgery
سال: 2011
ISSN: 0194-5998,1097-6817
DOI: 10.1177/0194599811416318a167